Yamamoto, 27, laid a fastball right down the middle to Tristan Peters, who cranked one near the right field foul pole to break it up with his third homer of the season.
Heading into Saturday, Yamamoto had allowed fewer than three hits in only one game this season. He tossed eight innings in his last start (June 6th) and allowed just two hits and one run against the Los Angeles Angels.
On Saturday, he finished with just the one hit, no walks, and seven strikeouts, and walked off the field receiving a standing ovation from both Dodgers and White Sox fans.
The Dodgers won the matchup 7-1 thanks to home runs from Shohei Ohtani and Max Muncy (2), and two RBI from Kyle Tucker.
Yamamoto almost completed a no-hitter during the 2025 season against the Baltimore Orioles. But the O's broke up the no-hitter with just one more out to go in the bottom of the ninth inning.
Following the perfect game against the White Sox, Yamamoto brought his season earned run average down to 2.52, while bringing his season strikeout total to 80.
Los Angeles improved to 45-26 on the season and sit atop the National League West division. They are just second to the Atlanta Braves, who possess the best record (46-24) in both the NL and all of baseball.