Spurs sit 18th in the standings on 34 points with four matches remaining as they desperately try to break out of the relegation zone under manager Roberto De Zerbi.
Pochettino, who spent five years as Tottenham manager, guiding the club to the Champions League final in 2019 before his departure a few months later, has spoken on the side potentially dropping down, which could crush the club.
"It is really sad. I really love Tottenham, and it is always going to be an important part of my life," Pochettino told The Overlap's Stick to Football podcast.
"It is really sad because I know how the people are suffering, inside the club and also the fans. It is difficult to accept."
Tottenham won their first Premier League fixture of 2026 last weekend with the narrow 1-0 victory at bottom side Wolves, but with West Ham also beating Everton, their three points were somewhat cancelled out.
That victory also came at a high cost, with Xavi Simons suffering an ACL injury that is expected to rule him out of the World Cup.
Dominic Solanke has also picked up a hamstring injury in recent weeks, adding to the club’s long list of injuries, which does not help their chances of staying up this season, as supporters and Pochettino prepare for the worst.