Guendouz hurt his knee on Monday in the Algerian league and did not make the 28-man selection for the tournament in neighbouring Morocco, leaving Zidane next in line.
The 27-year-old second son of Zinedine Zidane, who plays for Spanish second-tier side Granada, made his debut for Algeria in a World Cup qualifier in October after switching international allegiance, having played for France at junior level.
Zidane’s grandparents hail from the Kabylie region of Algeria, and he is expected to be ahead of Oussama Benbot and former first-choice keeper Anthony Mandrea in the pecking order for the finals in Morocco, where Algeria will compete in Group E against Burkina Faso, Equatorial Guinea and Sudan.
Mandrea won a surprise recall after being dropped when coach Vladimir Petkovic said he did not want to pick a keeper playing in the third tier of French football. Mandrea’s club, Caen, were relegated from Ligue 2 at the end of last season.
Algeria's squad includes striker Baghdad Bounedjah, who netted the winner in the 2019 Cup of Nations final against Senegal in Cairo.
The notable absentee is Olympique de Marseille attacker Amine Gouiri, who required shoulder surgery after the World Cup qualifier against Uganda in October and is not expected to play again until February. An injury ruled him out of the last Cup of Nations finals in the Ivory Coast two years ago.
Algeria's AFCON squad
Goalkeepers: Oussama Benbot (USM Alger), Luca Zidane (Granada), Anthony Mandrea (Caen)
Defenders: Ryan Ait-Nouri (Manchester City), Youcef Atal (Al Sadd), Zineddine Belaid (JS Kabylie), Rafik Belghani (Hellas Verona), Ramy Bensebaini (Borussia Dortmund), Samir Chergui (Paris FC), Mehdi Dorval (Bari), Jaouen Hadjam (Young Boys Berne), Aissa Mandi (Lille), Mohamed Amine Tougai (Esperance)
Midfielders: Houssem Aouar (Al Ittihad), Ismael Bennacer (Dinamo Zagreb), Hicham Boudaoui (Nice), Fares Chaibi (Eintracht Frankfurt), Ibrahim Maza (Bayer Leverkusen), Ramiz Zerrouki (Twente), Adem Zorgane (Union Saint-Gilloise)
Forwards: Mohamed Amoura (Werder Bremen), Monsef Bakrar (Dinamo Zagreb), Redouane Berkane (Al Wakrah), Adil Boulbina (Al Duhail), Baghdad Bounedjah (Al Shamal), Anis Hadj-Moussa (Feyenoord), Ilan Kebbal (Paris FC), Riyad Mahrez (Al Ahli)