Ohtani was taken out after five innings in which he gave up zero hits and zero runs while striking out five and walking just one on 68 pitches (42 strikes).
The National League MVP candidate has now thrown back-to-back shutouts, lowering his season earned run average to 3.29 in 13 starts. His next start will mark the 100th of his career.
The very next inning, the Phillies scored five straight runs off Dodgers relief pitcher Justin Wrobleski to take a 5-4 lead in the top of the sixth.
Edgardo Henriquez then came in for Wrobleski to finish the inning - but gave up a home run before doing so.
Ohtani, with a bat in his hands, is slashing .281/.395/.606 with 49 home runs and 93 RBI this season after starting Tuesday's game against the Phillies going 1-for-3 at the plate with a single and two strikeouts.
His 1.001 OPS makes him just one of two players in the majors with one above 1.000 - the other being Aaron Judge (1.127).
The 31-year-old needs six more home runs to set a career high, but is well short of getting near his 130 RBI total that he put up last season when he won MVP.
He's competing with Phillies star Kyle Schwarber for the National League MVP - who Ohtani struck out tonight.