England, set a record-breaking target of 457 for victory, were dismissed for 186 shortly before lunch on the final day of four, with off-spinner Sneh Rana (4-42) finishing the historic match when she bowled Sophie Ecclestone for 50.
India were dominant in all aspects of this four-day fixture - a game being played 142 years - and 150 matches - after Lord's staged its first men's Test.
Victory meant they ended their tour with happy memories of Lord's, having been knocked out of the T20 World Cup in the group phase at the 'Home of Cricket' by eventual champions Australia.
England, by contrast, struggled to adapt to the demands of the longer format in a match that started just days after their T20 World Cup final loss to Australia on July 5th.
The match was a personal triumph for India's Kranti Gaud and Yastika Bhatia, the first women to take five wickets and score a century respectively in a women's Test at Lord's.
Gaud took a superb 5-37 in England's first-innings 170 and wicket-keeper Bhatia's 113 was the cornerstone of India's imposing second-innings 341-7 declared.