Wood, who was cleared of a hamstring injury last week, will be part of a potent pace attack featuring Jofra Archer, Brydon Carse, Gus Atkinson and Ben Stokes.
Spinner Shoaib Bashir has also been added to the squad despite recent struggles, having recorded combined figures of 2/151 from 24 overs in a pre-Ashes warm-up match.
Ollie Pope has secured the number three batting spot ahead of Jacob Bethell, as England prepare for the opening test that begins in Perth on Friday.
England have not won a first Ashes test in Australia in nearly 40 years, nor beaten the hosts in Perth since 1978. But with Australia missing front-line quicks Pat Cummins and Josh Hazlewood, they are eyeing a golden opportunity heading into Friday's Ashes opener to strike the first blow in the five-test series.
England squad:
Ben Stokes (c), Jofra Archer, Gus Atkinson, Shoaib Bashir, Harry Brook, Brydon Carse, Zak Crawley, Ben Duckett, Ollie Pope, Joe Root, Jamie Smith (wicketkeeper), Mark Wood.