It makes it five straight Game 2 home wins for the Avalanche as they improved to 45-0-0 when leading after the second period this season.
The series now heads back to Minnesota for Game 3 on May 9th, when the Wild will try to dig themselves out of a deep hole as they are 1-8 all-time when trailing 2-0 in a playoff series.
Meanwhile, the Avs are 18-4 all-time when leading a playoff series 2-0.
Recap & Highlights
Much like Game 1, this time was no different, with both teams getting on the scoreboard early.
On the very first shot on goal from the Avs, Martin Necas scored his first of the playoffs to put Colorado up 1-0 just 2:51 after puck-drop.
Nathan MacKinnon (5) and Brett Kulak (2) picked up the assists.
It would take a measly six seconds for the Wild to respond with their first goal of the game on their second overall shot on net - the fifth-fastest between goals of opposing teams in Stanley Cup Playoffs history.
Kirill Kaprizov scored his third of the playoffs, with assists from Ryan Hartman (4) and Mats Zuccarello (5), to make it 1-1.
Zuccarello became the third player in Wild history to record a point in each of his first five playoff games with the team, joining Kaprizov and Zach Parise.
The Avs wouldn't respond within seconds, but it took them less than six minutes to go back up one.
Gabriel Landeskog scored his third goal of the playoffs after the Avs went on their first power play of the game, putting his squad up 2-1.
MacKinnon (6) and Martin Necas (6) both picked up the assists. It marked MacKinnon's 21st career multi-point playoff game, surpassing the great Joe Sakic for the most in franchise history.
Minnesota had a chance to tie things up with their first power play of the game after Colorado's Brock Nelson was called for a two-minute minor holding, but couldn't capitalize.
And it came back to bite them almost immediately to start the second period.
Colorado's Nicolas Roy scored his third of the playoffs on the team's first shot of the second period to make it a 3-1 game.
Ross Colton (2) and Nelson (1) recorded the assists.
The Avs eventually put the game completely out of reach after scoring for the second time on their fourth power play of the night.
After racking up two assists, MacKinnon decided to put one in the net himself for his fourth of the playoffs as the Avs took a 4-1 lead.
Nazem Kadri (3) and Landeskog (4) were credited with the assists. Colorado has now scored on three of their six power plays this series, despite having the 27th-ranked unit during the regular season.
MacKinnon also surpassed Peter Forsberg with his 59th career playoff goal, trailing only Sakic (84) for the most in franchise history.
Minnesota started to show some late life with under six minutes left to go in the third to cut the lead in half.
Marcus Johansson scored his third goal of the series to make it 4-2, with assists from Danila Yurov (2) and Daemon Hunt (1).
Unfortunately for the Wild, an ill-advised penalty from Kaprizov put them in a hole shortly after, which practically barred any hopes of a possible comeback.
Valeri Nichushkin scored his first goal of the series with an empty-netter for Colorado in the waning seconds of Game 2 to finally seal the deal.
Even during the loss, Minnesota outshot (31-23) and outhit (30-27) the Avalanche, while goalie Filip Gustavsson earned his first loss of the playoffs after getting the start over Jesper Wallstedt.
Scott Edgewood finished the game with 29 saves. He has only allowed more than two goals in a game these playoffs just once - their 9-6 Game 1 win over the Wild.