Pastrnak, 29, earned his 100th after assisting Morgan Geekie on his 39th goal of the season. The assist also marked Pastrnak's 71st assist of the year, which is tied with Evan Bouchard for the fifth-most in the league.
Pastrnak needs just one more goal to make it nine straight full seasons (2020 COVID season excluded) with at least 30 goals. In the past two seasons, the Czech Republic native has recorded at least 40 goals and 60 assists.
He won the 2019-2020 Richard Trophy after leading the league with 48 goals, earning him the first of two First-Team All-Star honors.
Pastrnak now has 420 goals and 513 assists through 833 career games.
Boston clinched a playoff spot this season and are now just playing for seeding.