Soto drove a solo shot to deep right field in the top of the third inning to give the Mets a 3-0 lead.
The home run was also caught from the umpire camera behind the plate.
Soto went 1-3 during Opening Day on Thursday and is currently 1-2 in this game.
The star outfielder signed a monstrous 15-year, $765 million deal with the Mets this offseason - which now goes down as the biggest contract in North American team sports history.