The 33-year-old from Curacao, who was banned 80 games last year after testing positive for a performance-enhancing drug, was issued a full-season and playoffs ban earlier this month after testing positive for "exogenous testosterone and its metabolites."
Profar had appealed the ban, only the sixth issued for a second performance-enhancing drug positive test since 2014 when MLB made a full-season suspension the penalty for second-time offenders.
As a result of the ban, Profar loses his $15 million salary for 2026 under the three-year deal worth $42 million he signed last year with the Braves.
Profar has an MLB career average of .245 with 995 hits, 125 home runs and 487 runs batted in over 13 MLB seasons with Texas, Oakland, San Diego, Colorado and Atlanta.