According to media reports on Wednesday, the Frenchman injured his knee ligaments and while he does not require surgery he faces a lengthy lay-off.
Fraser Forster (34) is Lloris's backup and looks set to have an extended run in the side having made only one Premier League appearance since joining on a free transfer.
Lloris's injury would be a blow to Tottenham who are fifth in the Premier League, face a last-16 Champions League tie against AC Milan and are also in the fifth round of the FA Cup.