With two spots at the finals in North America up for grabs, Guadalajara's Stadium will host the bracket where New Caledonia face Jamaica in the semi-final, with the winner advancing to meet DR Congo.
BBVA Stadium in Monterrey will stage the Bolivia–Suriname semi-final, with Iraq awaiting the winner. Both semis will be played on March 26th, with the two finals set for March 31st.
The single-leg knockout format ensures high-stakes ties as teams chase the last berths at the first-ever 48-team World Cup, which will be held in the United States, Mexico and Canada next year.
Local organisers said the playoffs would also serve as key operational tests, helping trial logistics, security and fan-movement plans with state and municipal authorities.
Monterrey and Guadalajara will each host four matches at the June 11th to July 19th World Cup.
Pedro Esquivel, head of the Monterrey organising committee, said on Thursday that BBVA Stadium was ready to host the matches ahead of schedule after undergoing renovations, including a new pitch and upgraded VIP boxes.
"If there were a game in January, we could host it without any problem," he said.
"We're working with the state and local authorities to treat these games as a trial for protocols and mobility, and we're coordinating closely with FIFA, which is keen for the event to be a success in Mexico."