The Argentina midfielder picked up his fifth yellow card of the Premier League campaign in Wednesday's 3-3 draw with Newcastle and will serve a one-match ban.
Liverpool will also be without Alisson and Ibrahima Konate while Diogo Jota and Federico Chiesa are also unlikely to feature at Goodison Park with a return close.
For Everton, they have no fresh injury concerns aside from defender Michael Keane, who is said to be a doubt.
Around the Premier League, defenders Gabriel and Riccardo Calafiori are still doubts for Arsenal's visit to Fulham after missing out on their 2-0 win over Manchester United in midweek.
Manchester City are going to be without Nathan Ake and Manuel Akanji when they travel to Crystal Palace and Tottenham have been dealt another defensive blow with Ben Davies set to miss their clash with Chelsea.
Check out all the doubts and absentees ahead of the next round of Premier League action:
Everton vs Liverpool
WON'T PLAY
Garner J. | Lower Back Injury
Iroegbunam T. | Ankle Injury
Alisson | Hamstring Injury
Bradley C. | Muscle Injury
Konate I. | Knee Injury
Mac Allister A. | Yellow Cards
Tsimikas K. | Ankle Injury
DOUBTS
Chermiti | Ankle Injury
Keane M. | Knee Injury
Chiesa F. | Lacking Match Fitness
Diogo Jota | Chest Injury
Aston Villa vs Southampton
WON'T PLAY
Ramsey J. | Hamstring Injury
Bazunu G. | Achilles Tendon Injury
Lallana A. | Thigh Injury
Larios J. | Injury
Ramsdale A. | Finger Injury
Smallbone W. | Thigh Injury
Stephens J. | Red Card
Stewart R. | Thigh Injury
DOUBTS
Onana A. | Foot Injury
Bednarek J. | Knee Injury
Onuachu P. | Injury
Brentford vs Newcastle
WON'T PLAY
Dasilva J. | Knee Injury
Gustavo Nunes | Back Injury
Henry R. | Knee Injury
Hickey A. | Thigh Injury
Jensen M. | Thigh Injury
Botman S. | Knee Injury
Krafth E. | Shoulder Injury
Lascelles J. | Knee Injury
DOUBTS
Ajer K. | Foot Injury
Trippier K. |Illness
Crystal Palace vs Manchester City
WON'T PLAY
Holding R. | Lacking Match Fitness
Matheus Franca | Muscle Injury
Wharton A. | Groin Injury
Akanji M. | Injury
Ake N. | Thigh Injury
Bobb O. | Leg Injury
Foden P. | Illness
Kovacic M. | Injury
DOUBTS
Stones J. | Health problems
Manchester United vs Nottingham Forest
WON'T PLAY
Manchester United
Lindelof V. | Muscle Injury
Shaw L. | Injury
Danilo | Ankle Injury
Sangare I. | Foot Injury
DOUBTS
Evans J. | Knock
Fulham vs Arsenal
WON'T PLAY
Andersen J. | Calf Injury
Cairney T. | Red Card
Nelson R. | Thigh Injury
Reed H. | Knee Injury
Tomiyasu T. | Knee Injury
White B. | Knee Injury
DOUBTS
Cuenca J. | Injury
Calafiori R. | Injury
Gabriel | Injury
Ipswich vs Bournemouth
WON'T PLAY
Donacien J. | Ankle Injury
Hirst G. | Knee Injury
Ogbene C. | Calf Injury
Tuanzebe A. | Thigh Injury
Araujo J. | Thigh Injury
Scott A. | Knee Injury
Sinisterra L. | Thigh Injury
DOUBTS
Cook L. | Muscle Injury
Leicester vs Brighton
WON'T PLAY
Fatawu I. | Knee Injury
Opoku N. | Broken Leg
Pereira R. | Thigh Injury
Stolarczyk J. | Ankle Injury
Winks H. | Muscle Injury
Hinshelwood J. | Knee Injury
Kadioglu F. | Toe Injury
March S. | Knee Injury
Milner J. | Thigh Injury
Webster A. | Muscle Injury
DOUBTS
Veltman J. | Muscle Injury
Tottenham vs Chelsea
WON'T PLAY
Bentancur R. | Suspended
Davies B. | Thigh Injury
Moore M. | Illness
Odobert W. | Thigh Injury
Richarlison | Thigh Injury
van de Ven M. | Thigh Injury
Vicario G. | Broken Ankle
Fofana W. | Muscle Injury | England
James R. | Thigh Injury | England
Kellyman O. | Muscle Injury
DOUBTS
None
West Ham vs Wolves
WON'T PLAY
TBC
TBC
DOUBTS
TBC