It will be the first chance for the Reds faithful to see their new signings at home in a competitive fixture, and it remains to be seen if Arne Slot will play all of Milos Kerkez, Jeremie Frimpong, Florian Wirtz and Hugo Ekitike, as he did against Crystal Palace in the Community Shield.
The Cherries arrive in the north west looking to change recent history in the fixture.
Not only have Liverpool won their last six home games against Bournemouth by an aggregate of 23-2, they've also won 11 of the last 12 English top-flight matches against them and haven't lost a season opener in 12 years.
Stats show Bournemouth could have an uphill struggle
It's the longest current run of any EPL side, with their last opening day defeat coming in 2012/13 against West Brom (0-3). Since then, the Reds have won nine and drawn three.
As reigning English top-flight champions, they've only lost once on opening day out of the 19 previous occasions (won 13, drew five), and that came way back in 1923/24, coincidentally against West Brom.
Bournemouth are unbeaten in their last seven opening day games though they too last lost against West Brom back in 2017/18.
The fixture offers up another quirk and an omen that home supporters might want to hang on to.
It's only the second time in Liverpool's long and illustrious history that they've started their league season on a Friday. The only previous occasion came in 2019/20 when Norwich were beaten 4-1 at Anfield, and the squad famously went on to lift their first Premier League title at the end of that campaign.
Reigning Premier League champions rarely lose on opening day
In the previous 33 Premier League seasons, the reigning champions have only lost on three occasions. Four games have been drawn with the other 26 being wins for the team that had a tight hold on the silverware.
Mo Salah will be looking to continue where he left off last season, and the Egyptian King normally has rich pickings against the south coast outfit.
11 goals scored against them is the most of any Premier League player, and his nine goals on opening day is also way ahead of anyone else.
Furthermore, with 105 goals scored at Anfield, he only needs another 10 to be the player with the most league goals scored - currently Thierry Henry's 114 - at a single stadium in Premier League history.
If Wirtz does score on Friday, he'll become just the third German to open his account on the EPL's opening day, following in the footsteps of Jurgen Klinsmann (1994) and Ilkay Gundogan (2016).
It isn't just his goals that oil the wheels either, with his 12 assists for Bayer Leverkusen last season seeing him become one of only five players in the top five European leagues to hit double figures for both goals (10) and assists.
Cherries without five players
Given that Andoni Iraola won't be able to call upon the services of Justin Kluivert, Ryan Christie, Lewis Cook, Luis Sinisterra and Enes Unal, it's going to be a very tall order for Bournemouth to get any sort of foothold in the game.
Their brand of football has been a joy to watch under their Basque coach, however, it's difficult to see where they can better their opponents anywhere across the pitch.
Kerkez left them to join the Reds of course, and his replacement, Adrien Truffert, may have his work cut out in trying to keep Frimpong's influence down Liverpool's right-hand side to a minimum.
If Andrew Robertson is again left out of the starting XI, Kerkez will get an immediate reunion with his old club, and given that they know all about his talents doubling up on him at every opportunity is almost a certainty.
Indeed, the pace from wide areas coupled with a creative hub centrally in Wirtz gives Liverpool some serious attacking options, and new Bournemouth centre-back, Bafode Diakite, could have a baptism of fire on debut.
Bournemouth need to take a leaf out of Palace and Forest's book
As Palace showed on more than one occasion in the Charity Shield, however, that consistent raiding down the channels comes at a cost.
The high-risk, high-reward strategy can be picked apart by balls over the top and into the wider areas, forcing either Virgil van Dijk or Ibrahima Konate to desert their usual position in order to cover their colleagues.
Should Bournemouth's play have a little bit of zip about it and the Cherries approach the game with confidence rather than the whipping boys everyone expects, there's the slightest of chances that they could spring a huge surprise.
If they're looking for a blueprint to follow, they only need review the footage from Nottingham Forest's win at Anfield in 2024/25 as an indicator of what's possible with the right application and mindset.
