The new 12-team competition aims to bring structure to the international calendar, replacing the current system in which European sides tour the southern hemisphere in June before hosting their southern counterparts in standalone November tests.
The tournament begins on July 4 with New Zealand hosting France in Christchurch, with South Africa against England in Johannesburg the pick of the rest of the day's games.
Action moves to Europe in November, culminating in a finals weekend in London, where the top two teams will meet at Twickenham on November 29.
“The schedule of fixtures and kick off times across the tournament highlight the commitment to give global fans access to an incredible set of clashes and structured in a way that means they need never miss a moment of the action,” said Six Nations CEO Tom Harrison.
“This is enhanced by incredible broadcast partnerships, including major Free-To-Air access across some of the biggest rugby markets in the world.
"When the Nations Championship kicks off, it will put the players, teams, and sport on the global stage, ushering in a new chapter in rugby’s history.”
Southern Series (July)
July 4: New Zealand v France, Japan v Italy, Australia v Ireland, Fiji v Wales (in Wales), South Africa v England, Argentina v Scotland
July 10-11: Fiji v England (in England), New Zealand v Italy, Australia v France, Japan v Ireland (in Australia), Sout Africa v Auckland, Argentina v Wales
July 17-18: Fiji v Scotland (in Scotland), New Zealand v Ireland, Japan v France, Australia v Italy, South Africa v Wales, Argentina v England
Northern Series (November)
November 6-8: Ireland v Argentina, Italy v South Africa, Scotland v New Zealand, Wales v Japan, France v Fiji, England v Australia
November 13-15: France v South Africa, Italy v Argentina, Wales v New Zealand, England v Japan, Ireland v Fiji, Scotland v Australia
November 20-21: France v Argentina, England v New Zealand, Scotland v Japan, Ireland v South Africa, Italy v Fiji, Wales v Australia
Finals weekend (November)
November 27-29: 6th North v 6th South, 5th North v 5th South, 4th North v 4th South, 3rd North v 3rd South, 2nd North v 2nd South, 1st North v 1st South