The former Tour de France winner was seen as one of the very few riders capable of preventing rival Tadej Pogačar from winning back-to-back rainbow jerseys, but he has chosen to focus on the European Championships instead.
"No, actually, yeah, we decided not to go to the Worlds. It doesn't really fit into the plans," said Vingegaard over a video call.
"We have decided, though, that we want to go for the Europeans instead. Of course, you need to be really fresh and everything to go to the World Championships this year – it really requires a lot from the rider who's participating."
"With not knowing how I'm going to come out of this Vuelta, and with how I experience it now, then we decided that it was better to to not do it and then say 'I still want to do the European Championships and that I can do that instead', then I'll have some time after the Vuelta to focus on that."
Vingegaard has suffered from illness in his preparations for the Vuelta where Pogačar will not take part, but seems rejuvenated in what feels like a must-win Vuelta for the Dane.
"To be honest, I had a good training period. I did almost everything I wanted," said Vingegaard.
"I just had a small, small setback, but that was really, a really minor and, yeah, I feel like the shape is good and I'm ready for the next three weeks of racing. I had a small, small sickness. But, as I said, it was very, very minor, and I don't feel like it affected me."