Flashscore's NFL Week 5 matchup picks

Seahawks wide receiver Jackson Smith-Njigba
Seahawks wide receiver Jackson Smith-NjigbaJane Gershovich/Getty Images

Our experts are back again to give their Week 5 picks of the 2025 NFL Season!

Thursday night gave us yet another fantastic NFC West matchup for the second week in a row as the San Francisco 49ers defeated the Los Angeles Rams in overtime.

Because of the 49ers' upset, all of our staff head into Sunday's matchup 0-1 on the week. 

On Sunday, the Minnesota Vikings and Cleveland Browns will clash in the season's first London game. Minnesota is coming off a loss to the Pittsburgh Steelers from their matchup in Dublin, Ireland, last week. 

Click here for all information on the NFL's international games.

As for the uniform matchup of the week, the Tampa Bay Buccaneers will be rocking their creamsicle all-white 1976 throwbacks in their game against the Seattle Seahawks, who will be repping their gorgeous throwbacks as well. 

On Sunday night, the New England Patriots are taking on the Buffalo Bills in the only other division matchup for the rest of Week 5. 

New England is 2-2 and coming off their biggest win of the season (48-10), while the Bills are just one of two remaining undefeated teams, with the other being the Philadelphia Eagles

On Monday night, the 2-2 Kansas City Chiefs will face the 3-1 Jacksonville Jaguars, who are looking to go 4-1 in their first five games for the first time since 2007 - a year they finished with an 11-5 record. 

The Atlanta Falcons, Chicago Bears, Green Bay Packers, and Pittsburgh Steelers are all on a bye week.

Now, time for our experts' picks!

Miguel took the crown yet again this past week after correctly predicting 12 of the 16 games. Here are the current standings heading into Week 5:

Miguel: 45-18-1

Paul: 39-24-1

Eric: 36-27-1

Henri: 34-29-1

Here's who they picked for Week 5!

Week 5 picks
Week 5 picksFlashscore
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