Irishman McGregor, the organisation's former featherweight and lightweight champion and the first UFC fighter to hold two world titles simultaneously, has not fought since suffering a gruesome leg break against Dustin Poirier in July 2021.
The 34-year-old will pit his wits against American Chandler as the two coach teams of up-and-coming fighters against each other in the TV series, which begins on ESPN on May 30, with the pair scheduled to meet when the season ends.